Protein Details: Aquaporin-4

Protein ID

ICDB_Pro_0539

Protein Name

Aquaporin-4

Gene Name

Aqp4

Organism

Rattus norvegicus (Rat)

Length

323 amino acids

AlphaFoldDB

AF-P47863-F1-model_v4.pdb

Function

Forms a water-specific channel . Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries; and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby; it is required for normal clearance of solutes from the brain interstitial fluid; including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).

Sequence

MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV

PDB Structures

2D57 2ZZ9 3IYZ

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in cerebellum (PubMed:18179769; PubMed:29055082). Detected on pericapillary astrocyte endfeet in cerebellum; and in skeletal muscle (PubMed:29055082). Detected in glial lamellae in the hypothalamus (at protein level) (PubMed:16325200). Detected in glial lamellae in the hypothalamus (at protein level) (PubMed:16325200). Detected in glial lamellae in the hypothalamus (at protein level) (PubMed:16325200). Abundant in mature brain cortex; cerebellum and spinal cord. Highly expressed in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space. Detected in paraventricular and supraoptic nuclei; the granule cell layer of the dentate gyrus and the Purkinje cell layer in the cerebellum. Only weakly detectable in eye; kidney; intestine; and lung (PubMed:7528931)...

DOI ID

10.1073/pnas.91.26.13052; 10.1016/s0021-9258(17)37486-0; 10.1038/nature02426; 10.1016/s0006-291x(02)02296-9; 10.1038/nbt819; 10.1073/pnas.0600895103; 10.1016/j.bbamem.2007.12.007; 10.1016/j.neuroscience.2009.09.072; 10.1038/ncomms1871; 10.1111/jcmm.13401; 10.1016/j.jmb.2005.10.081; 10.1016/j.jmb.2009.04.049

RefSeq

NP_001135838.1 [P47863-3]; NP_001257487.1 [P47863-2]; NP_036957.1 [P47863-1]; XP_017456346.1